Nancy Drew: The White Wolf of Icicle Creek finds Nancy far from home in the middle of the Canadian Rockies to investigate several suspicious accidents occurring at Chantal's spooky Icicle Creek Lodge. To make matters worse, an eerie wolf's howl in the distance is haunting the guests at night, causing Nancy to wonder if the accidents and the mysterious wolf are connected.

Assuming the role of Nancy Drew, players embark on a mystery adventure that will tax their deductive reasoning skills as they tackle intricate puzzles and master a variety of gesture-based mini-games with the Wii Remote. Additionally, Nancy Drew: The White Wolf of Icicle Creek lets players choose either a Junior or Senior Detective level, making it a perfect game for players of all skill levels.